New Delhi: A Team of Indian Scientists has found a new way to treat liver Cirrhosis, by targeting the lymphatic vessels in the liver and intestine that fail in case of arff.

Chronic Liver Disease Can Progress from Mild Disease to Fibrosis to Cirrhosis (also know as scarring).

Cirrhosis is accommodated by the distortion of both blood and lymphatic vessels in the liver and the Intestine. Patients with Advanced Cirrhosis often Develop Complications Like Fluid Accumulation in the Abdomen.

A team of scientists from the institute of liver and biliary science (ILBS), New Delhi, and National Institute of Pharmaceutical Education and Research (Niper), GUWAHATI, GUWAHATI, GUWAHATI of lymphatic vessels in the liver and intestine by using nanocarriers filled with a powerful protein called vegf-c.

Pic credits: IANS

“Vascular endothelial growth factor-c (vegf-c) is a key pro-lymphangioganic factor that activations lymphangiogenies or new lymphatic vessel grouvth. Membrane Tyrosine Kinase Receptor, Vascular Endothelial Growth Factor Receptor-3 (VegfR-3), The activation of which is essential for the growth and development of new lymphatic vessels, ” Researches.

The team probed the therapeutic efficacy of vegf-c in amented gut lymphatic dysfunction and improving lymph drainage.

Owing to the Hydrophilicity, Short Half-Life, and Systemic Side Effects of Vegf-C, The TEAM LED by Dr Subham Baneerjee from Niper Niper Guwahati first focused Reverse Micelle-Based Nanocarries, which specifically bind to vegfr-3 homodimers.

Next, The Ilbs Team, LED by Dr Savneet Kaur, Tested The Developed Vegf-C Nanocarriers Extensively in Animal Models of Advanced Cirrhosis and Portal Hypertension.

The developed molecule was delivered via the Oral route to ensure its gut lymphatic vessel uptake in the animal models. The team showed that vegf-c nanocarriers significantly increased Mesenteric lymph drainage, which reduced ascites.

Importantly, the treatment also LED to an attenuation of the portal pressures, improved cytotoxic t-cael immunity in mesenteric lymph nodes, and reducked Local and Systemic Bacterial Load.

The research, published in the jhep reports Journal, is the first to highlight that therapeutic lymphangiogenesis with vegf-c is a promising treatment for reconstructing the frGMPHATIC NETWORKTION Restoring lymphatic function and drainage in advanced cirrhosis.